中文摘要：

目的探讨围生期暴露双酚A（bisphen01A，BPA）对青春期雌性子代大鼠体重、糖代谢及细胞炎症因子的影响。方法将21只清洁级SD妊娠大鼠分为3组，分别为对照（含1％无水乙醇的水）组和低（1μg／ml）、高（10μg／ml）浓度BPA暴露组，每组7只。从妊娠第6天至哺乳期（出生后20d），母鼠采用自由饮水方式进行染毒；断乳后，雌性仔鼠采用自由饮水（不含BPA）方式继续喂养30d。测定雌性仔鼠体重、空腹血糖、胰岛素水平及血清肿瘤坏死因子-α（tumornecrosisfactor-α，TNF-α）和白介素6（interleukin-6，IL-6）水平，并计算胰岛素抵抗指数。结果各浓度BPA暴露组雌性仔鼠体重、空腹血糖、血清胰岛素水平和胰岛素抵抗指数、TNF-α、IL-6水平均明显高于对照组，差异有统计学意义（P〈0．05，P〈0．01）。结论围生期暴露BPA可引起子代雌性大鼠体重增高和胰岛素抵抗，并可诱发机体炎症反应。

英文摘要：

Objective To explore the effects of perinatal exposure to bisphenol A（BPA） on body weight and inflammatory factors in adolescent female offspring rats. Methods A total of 21 pregnant Sprague-Dawley rats were randomly divided into three groups, seven rats in each group, the control group （1% of anhydrous alcohol with water）,low dose （1 μg/ml） and high dose （10 μg/ml） groups of BPA exposed through drinking water,from gestation day 6 to the end of lactation respectively. Female offspring drank water without BPA for 30 days after weaning. Body weight,fasting serum glucose,insulin,necrosis factor-α （TNF-α） and interleukin-6 （IL-6） levels were determined, and insulin resistance index was calculated in female offspring after postnatal day 50. Results There were significantly higher body weight,serum glucose,insulin,and insulin resistance index,TNF-α and IL-6 levels in BPA-exposed female rats compared with the controls （P〈0.05 or P〈0.01）. Conclusion Perinatal exposure to BPA may result in body weight gain and insulin resistance,and induce inflammatory response in female offspring.