中文摘要：

目的评价非药物物理训练和生酮饮食对发育期惊厥性脑损伤神经行为的影响。方法通过计算机检索PubMed、EMBASE、OVIDMEDLINE、中国生物医学文献数据库（CBM）、中国期刊全文数据库、万方数据库、重庆维普中文科技期刊全文库（从建库至2012年8月）中的中英文文献，并按纳入、排除标准纳入合格的随机对照研究并对其进行质量评价，Meta分析采用RevMan5．1软件进行。结果1．物理训练干预：符合纳入标准的文献共6篇，包括2篇中文文献和4篇英文文献。分别比较单纯惊厥组和惊厥加运动训练组、单纯对照组和对照加运动训练组之间的差异。Meta分析结果显示：单纯惊厥组与惊厥加运动训练组之间水迷宫逃避潜伏期的差异有统计学意义（WMD=13．96，95％CI：8．46～19．46，P〈0．00001）；单纯对照组与对照加运动训练组之间水迷宫逃避潜伏期的差异无统计学意义（WMD=-1．53，95％CI：-6．77～3．70，P=0．57）。2．生酮饮食干预：共纳入文献5篇，其中2篇中文文献，3篇英文文献。分别比较正常饮食组与正常生酮饮食组、单纯惊厥组与惊厥加生酮饮食组之间的差异。Meta分析结果显示：（1）正常饮食组与正常生酮饮食组旷场实验开场得分及水迷宫逃避潜伏期的差异均有统计学意义（WMD=18．82、8．80，95％CI：15．64～22．01、1．48～16．12，P〈0．00001、P=0．02）。（2）单纯惊厥组与惊厥加生酮饮食组旷场实验开场得分及逃避潜伏期的差异均无统计学意义（WMD=-23．72、7．16，95％CI：-98．55～51．11、-0．52—14．84，P=0．53、0．07）。单纯惊厥组与惊厥加生酮饮食组放电阈值的差异有统计学意义（WMD=34．57，95％CI：16．46～52．69，P=0．0002）。结论非药物手段如物理训练和生酮饮食对发育期惊厥性脑损伤有保护作用，但生酮饮食对健康大鼠的神经行为有损害作用，目

英文摘要：

Objective To assess the effects of non-pharmacological means physical exercise and ketogenic diet on neurobehavior of developmental rats with recurrent seizures. Methods Chinese and English literatures from PubMed, EMBASE, OVID MEDLINE, Chinese Biomedical Literature Database （ CBM ）, Academic literature database, Wan fang database, Chongqing Chinese Science and Technology Periodical Database （ the time of building a database - August 2012） by the computer were researched. Those articles according to inclusion and exclusion criterias were inclusived qualified randomized controlled studies and their quality were evaluated. Then the Meta-analysis was performed by Rev Man 5.1. Results 1. Physical exercise intervention ： Six articles were included according to the inclusion criterias, 2 in Chinese,4 in English. The differences among recurrent-seizure and non-exercise （RS ＋ NE） group, recurrent-sei- zure and physical exercise （RS ＋ PE） group, non-seizure and non-exercise（ NS ＋ NE） group, non-seizure and physical exercise （ NS ＋ PE） group were respectively compared. There was significant difference in escape latency between RS ＋ NE group and RS ＋ PE group （ WMD = 13.96,95 % CI： 8.46 - 19.46, P 〈 0. 000 01 ）. There was no significant difference in escape latency between NS ＋ NE group and NS ＋ PE group（ WMD = - 1.53,95% CI： -6.77 -3.70,P = 0. 57）. 2. Ketogenic diet intervention ： Five articles were included, 2 in Chinese, 3 in English. The differences among non-seizure and normal diet （NS ＋ ND） group,non-seizure and ketogenic diet （NS ＋ KD） group,recurrent-seizure and normal diet （RS ＋ ND） group,recurrent-seizure and ketogenic diet（ RS ＋ KD） group were respectively compared. （1） There were significant differences in scores and escape latency between NS ＋ ND group and NS ＋ KD group （ WMD = 18.82,8.80,95 % CI：1 5.64 -22.01,1.48 - 16.12, P 〈 0. 000 01, P = 0.02）. （2）There was no significant difference in scores and escape la