中文摘要：

Toll样受体，尤其是TLR-2及TLR-4作为介导天然免疫反应的一类跨膜受体蛋白在大血管病变中的作用日益引起关注。目前I临床常见大血管病变以动脉粥样硬化为主，Toll样受体可通过多途径影响动脉粥样硬化进程。前期研究发现，糖尿病合并的周围血管病变中，动脉损伤的表现以纤维性病变为主，但当前对于动脉纤维化的诊断及治疗尚缺乏一个统一的标准，原因主要是对动脉纤维化的机理没有一个完整的认识，但Toll样受体对器官纤维化的机制已被广泛证实。该文主要就Toll样受体在动脉粥样硬化、器官纤维化治疗及机理的研究方面做一综述，以期对动脉纤维化进一步研究。

英文摘要：

Toll-like receptors, especially TLR - 2 and TLR - 4, which could induce the innate immune response, are grabbing more attention for the effect of the diseased great vessels. At present, the common diseased great vessel is atherosclerosis. Toll-like receptors can influence the process of atheroselerosis in many ways. We found that arteries fibrosis is a prime symptom in diabetic peripheral vasculopathy. The mechanism of arteries fibrosis is not completely examined now, and the diagnosis and theapy don＇t have an uniform conclusion either, but the mechanism of organ fibrosis has been widely confirmed. This article is a summary of introducing the mechanism and theapy of atherosclerosis and organ fibrosis with Toll-like receptors for the arterial fibrosis for further study.