中文摘要：

瞄准：评估外科手术前的 transcatheter 的效果动脉的 chemoembolization (不作声) 在肝细胞的增长上癌(HCC ) 房间。方法：有 HCC 的 136 个病人的一个总数经历了肝切除术。136 个病人， 79 个病人收到了 1 ～ 5 堂功课在肝切除术以前不作声(不作声组) ，进一步被细分进四的人，组织：组 A (n = 11 ) 独自收到了化疗的 1 ～ 4 堂功课；组 B (n = 33 ) 收到了化疗的 1 ～ 5 堂功课的人，与碘油结合了；组 C (n = 23 ) 收到了化疗的 1 ～ 3 堂功课的人，与碘油和明胶海绵结合了；并且组织 D (n = 12 ) 收到了化疗的 1 ～ 3 堂功课的人，与碘油，乙醇和明胶海绵结合了。另外的 57 个病人仅仅收到了肝切除术(非不作声的组) 。Ki-67 和增殖的房间的表情原子抗原(PCNA ) 蛋白质被免疫在肝癌症纸巾检测组织化学的方法。结果：Ki-67 蛋白质表示作为与非不作声的组相比在组 C 和 D 是显著地更低的(31.35%+/-10.85% 对 44.43%+/-20.70% ， 30.93%+/-18.10% 对 44.43%+/-20.70% ，分别地 P 【 0.05 ) 。PCNA 蛋白质表示作为与非不作声的组相比在组 C 和 D 是显著地更低的(49.61%+/-15.11% 对 62.92%+/-17.21% ， 41.16%+/-11.83% 对 62.92%+/-17.21% ，分别地 P 【 0.05 ) 。Ki-67 蛋白质表示作为与非不作声的组相比在组 A 是显著地更高的(55.44%+/-13.72% 对 44.43%+/-20.70% ， P 【 0.05 ) 。PCNA 蛋白质表示作为与非不作声的组相比在组 A 和 B 是显著地更高的(72.22%+/-8.71% 对 62.92%+/-17.21% ， 69.91%+/-13.38% 对 62.92%+/-17.21% ，分别地 P 【 0.05 ) 。结论：外科手术前的多材料不作声压制 HCC 房间的增长，当单个材料 embolization 和化疗独自提高 HCC 房间的增长时。

英文摘要：

AIM： To evaluate the effect of preoperative transcatheter arterial chemoembolization （TACE） on proliferation of hepatocellular carcinoma （HCC） cells. METHODS： A total of 136 patients with HCC underwent liver resection. Of 136 patients, 79 patients received 1 to 5 courses of TACE prior to liver resection （TACE group）, who were further subdivided into four groups： Group A （n = 11） who received i to 4 courses of chemotherapy alone; Group B （n = 33） who received i to 5 courses of chemotherapy combined with iodized oil; Group C （n = 23） who received i to 3 courses of chemotherapy combined with iodized oil and gelatin sponge; and Group D （n = 12） who received 1 to 3 courses of chemotherapy combined with iodized oil, ethanol and gelatin sponge. The other 57 patients only received liver resection （non- TACE group）. The expressions of Ki-67 and proliferating cell nuclear antigen （PCNA） protein were detected in the liver cancer tissues by immunohistochemical method. RESULTS： The Ki-67 protein expression was significantly lower in Groups C and D as compared with non-TACE group （31.35% ± 10.85% vs 44.43% ± 20.70%, 30.93% ± 18.10% vs 44.43% ± 20.70%, respectively, P 〈 0.05）. The PCNA protein expression was significantly lower in Groups C and D as compared with non-TACE group （49.61% ± 15.11% vs 62.92% ± 17.21%, 41.16% ± 11.83% vs 62.92% ± 17.21%, respectively, P 〈 0.05）. The Ki-67 protein expression was significantly higher in Group A as compared with non-TACE group （55.44% ± 13.72% vs 44.43% ± 20.70%, P 〈 0.05）. The PCNA protein expression was significantly higher in Groups A and B as compared with non-TACE group （72.22% ± 8.71% vs 62.92% ± 17.21%, 69.91% ± 13.38% vs 62.92% ± 17.21%, respectively, P 〈0.05）. CONCLUSION： Preoperative multi-material TACE suppresses the proliferation of HCC cells, while a single material embolization and chemotherapy alone enhance the proliferation of HCC cells.