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Mineralized Composite Nanofibrous Mats for Bone Tissue Engineering

分类：R318.08[医药卫生—生物医学工程;医药卫生—基础医学]
作者机构：State Key Laboratory for Modifications of Chemical Fiber and Polymer Materials,College of Material Science and Engineering,Donghua University, Biomaterials and Tissue Engineering Laboratory,College of Chemistry,Chemical Engineering and Biotechnology,Donghua University, College of Materials and Textile Engineering,Jiaxing University, School of Materials Science and Engineering,Nanyang Technological University, Department of Mechanical Engineering,National University of Singapore
相关基金：“111 Project”Biomedical Textile Materials Science and Technology,China(No.B07024);National Natural Science Foundations of China(No.31070871,No.31271035);National Medical Research Council,China(No.NMRC/1151/2008);Technologies Bureau of Jiaxing City,China(No.MTC2012-006,No.2011A Y1026);Science and Technology Agency of Zhejiang Province,China(No.2012R10012-09)

作者：刘威, 詹建朝, 吴桐, 苏艳, 莫秀梅, 廖素三, RAMAKRISHNA Seeram

关键词： electrospnning, nanofibrous, MAT, MINERALIZATION, BONE, TISSUE, ENGINEERING

中文摘要：

Composite nanofibrous mats consisting of poly( L-lactideco-ε-caprolactone)( PLCL) and collagen type I( COL) were fabricated by electrospinning,and ten times simulated body fluid(10SBF) were employed to mineralize nanofibrous mats. Ballshaped hydroxyapatite( HA) was deposited on the surface of nanofibrous mats in 1. 5 h at room temperature. Human fetal osteoblasts( hFob) were seeded to investigate their proliferation and differentiation on mineralized composite nanofibrous mats. The results showed that hFob grew well on mineralized composite nanofibrous mats and alkaline phosphatase( ALP) activity of hFob on mineralized composite nanofibrous mats at 14 d was much higher than that on untreated nanofibrous mats. Moreover,the expression of osteocalcin of cells on mineralized composite nanofibrous mats was also much higher than those on untreated nanofibrous mats at 7 d and 14 d. This mineralized composite nanofibrous mats may have a great potential for bone tissue engineering.

英文摘要：

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