中文摘要：

脑白质损伤可导致髓鞘损害和神经纤维不能髓鞘化,是脑瘫、智力和视听障碍的主要原因。目前,促进神经再生的内在修复潜能正趋向于成为治疗脑白质损伤的重要策略。近来发现一种新的P2Y受体——GPR17可能调控脑白质损伤后的内在修复潜能。文章将就脑白质的解剖特点、少突胶质细胞的生物学特性及GPR17在脑白质损伤后内在修复中的作用进行综述。

英文摘要：

Cerebral white matter injury which can result in the myelinoclasis and the dysmyelination of nerve fibers is a major reason for leading cerebral palsy,mental retardation,and visual-hearing impairment.Recently promo-ting the inherent self-repairing potential of nerve regeneration tends to become an important strategy for the treatment of cerebral white matter injury.A new identified P2Y-like receptor GPR17 may probably regulate the inherent self-repairing potential after cerebral white matter injury.The paper reviews the anatomical features of the white matter,the biological characteristics of oligodendrocytes,and the possible role of GPR17 in the inherent repairing of cerebral white matter injury.