中文摘要：

细菌耐药性是导致现代抗生素使用药效下降的最主要原因之一,几乎所有结构类别的抗生素能够诱导不同的细菌产生耐药响应.综述了细菌产生耐药性的主要途径和抗生素增效剂的研究进展.从解除耐药能力和拮抗耐药靶点两方面总结了抗生素增效剂的研发策略.展示抗生素增效剂广阔的应用前景.

英文摘要：

Bacterial resistance is one of the most important reasons for the decline in drug efficacy of modern antibiotics,and almost all antibiotics can induce the bacteria resistance.The main pathway of different bacteria resistances was expounded in details.Based on the analysis of the different mechanisms destroying bacteria resistances and killing the machine tools of making the bacteria resistances,a new synergist strategy for developing new pharmaceutical against bacteria resistance was proposed.The wide prospect of the application of antibiotic synergist was presented.