中文摘要：

胆道支架不仅要求具备优异的力学性能,更重要的是材料在胆道环境中具有良好的生物相容性。采用非平衡磁控溅射设备在不锈钢基体上制备了Ti-O薄膜,研究了其结构及与病人胆汁相互作用。结果表明,Ti-O膜表面具有较高的表面能,不利于细菌粘附及生物膜形成,胆汁稳定性和胆红素变化也是影响支架材料相容性的主要原因,这对开发新型胆道支架材料提供了研究依据。

英文摘要：

The newly developed biliary stent should have good mechanical properties,as well as excellent biocompatibility in order to meet the needs of reducing immunological reaction in vivo.In this work,Ti-O film was deposited on 316L stainless steel（316L SS） by unbalanced magnetron sputtering device,and the structure of Ti-O film was characterized by X-ray diffraction（XRD）.The interaction of Ti-O film and bile was also investigated by incubating in human fresh bile.The results showed that the surface of Ti-O film could reduce bacteria adherence and form bacterial biofilm owing to more surface energy.The mesobilirubin reducing and the change of the stability of bile are other factors of evaluating biocompatibility.It＇s important to develop new biliary stent materials based on its biocompatibility.