中文摘要：

目的：探讨E-钙粘蛋白（E-Cad）与胚胎停育的关系。方法：选取胚胎停止发育妇女为实验组，同期正常早孕自愿要求流产的妇女为对照组，分别留取其绒毛和蜕膜组织标本，采用荧光实时定量PCR（Realtime—PCR）对标本E—Cad mRNA转录水平进行分析。结果：在绒毛标本中，E—Cad在实验组中mRNA表达水平（0．875±0．07）显著高于对照组（0．337±0．11）；在蜕膜标本中，实验组E—Cad mRNA的表达水平（O．927±0．12）显著高于对照组（0．512±0．08）。结论：E—Cad的差异表达可能参与了胚胎停育的发生及发展，蜕膜和绒毛组织中E—Cad的高表达可能是导致早期胚胎停育的原因之一。

英文摘要：

Objective： The relationship between E-Cad and embryos damage. Methods：Select embryos damage women as the experimental group, the same period in normal early pregnancy voluntarily request the abortion of women as a control group,respectively,leaving whichever villi and decidual tissue, using a real-time quantitative PCR （RT-PCR） of specimens E-Cad mRNA transcription level analysis. Results l Villus samples, E-Cad expression levels in the experimental group（0. 875±0.07）was significantly higher than that in the control group （0. 337±0. 11）. in the decidual specimens, E-Cad mRNA expression levels of the experimental group（0. 927±0.12）was signifi- candy higher than that in the control group（0. 512 ±0.08）. Conclusion： The differences in the expression of E-Cad may be involved in the occurrence and development of the embryos damage. Decidua and chorionic villi high expres- sion of E-Cad probably one of the reasons why early embryos damage.