中文摘要：

目的：研究接骨木总苷片促进骨折愈合与抗炎作用。方法：复制兔骨折模型。60只新西兰大白兔随机均分为正常对照（等容生理盐水）组、模型（等容生理盐水）组、跌打丸（0.28 g/kg）组与接骨木总苷片高、中、低剂量（0.22、0.11、0.06 g/kg）组,以药物加入饲料给药,连续36 d。骨密度仪测定骨密度（BMD）、骨矿含量（BMC）、骨痂面积（Area）,通过X光片观察兔骨折愈合程度。采用小鼠耳肿胀和大鼠足肿胀模型观察其抗炎作用,热板法观察其镇痛作用。结果：高、中、低剂量接骨木总苷片可增加模型大白兔BMD、BMC,使模型大白兔骨折断端接近消失,骨膜反应密度加深,骨痂量增多、增深;中剂量组接骨木总苷片可增加模型大白兔Area。高、中、低剂量接骨木总苷片可减轻模型小鼠耳肿胀度,降低模型大鼠足肿胀率,提高1 h内模型小鼠痛阈值。结论：接骨木总苷片有较好的抵抗急性炎症和镇痛的作用,并能促进骨折愈合。

英文摘要：

OBJECTIVE：To study the effects of Sambucus williamsii total glycosides tablets on fracture healing and inflammation. METHODS：Rabbit fracture model was induced. 50 New Zealand white rabbits were randomly divided into normal control group（constant volume of normal saline）,model group（constant volume of normal saline）,Dieda pills group（0.28 g/kg）,S. williamsii total glycosides tablets high-dose,medium-dose and low-dose groups（0.22,0.11,0.06 g/kg）. They were given medicine via feedingstuff for consecutive 36 d. The bone mineral density（BMD）,bone mineral content（BMC）and callus area（Area）were determined by dual energy X-ray absorptionmetry（DXA）. The degree of fracture healing was observed by X-ray film. Anti-inflammatory effects were observed by mice ear swelling and rat foot swelling experiments;analgesic action was observed by hot plate method. RESULTS：High-dose,medium-dose and low-dose of S. williamsii total glycosides tablets could increase BMD and BMC in model group;the fracture site of model rabbit disappeared nearly,and periosteal reaction density increased and deepened. Medium-dose of S. williamsii total glycosides tablets could increase Area in model group. High-dose,medium-dose and low-dose of S.williamsii total glycosides tablets relieved mice ear swelling of model mice and foot swelling of model rats,and increased 1h pain threshold of normal mice. CONCLUSIONS：S. williamsii total glycosides tablets have good resistance to acute inflammation and analgesic effect and can promote the fracture healing.