中文摘要：

RNA激活是最近发现在转录水平激活目的基因表达的新的RNA调控方式,能够激活基因转录的小分子RNA被称为小激活RNA（saRNA）。和siRNA的沉默效果相比,RNAa的激活作用更为持久,具有更为广泛的肿瘤治疗范围,有可能成为基因功能研究及疾病治疗的一种新的有效工具。

英文摘要：

RNA activation （RNAa） is a newly discovered model for RNA-regulated gene expression. The process is triggered by double-stranded RNA （dsRNA） molecules, resulting in de novo expression of the target genes at the transcriptional level. These RNA molecules are termed as small activating RNAs （saRNA）. The saRNA-induced gene expression can last relatively longer than siRNA-induced gene silencing. Therefore, it represents a potential means in disease intervention.