中文摘要：

背景曲霉属菌 fumigatus ( A.fumigatus )是为在经历化疗的病人的侵略模子感染的多数负责的无所不在的腐生的真菌，机关移植或与学习试图在人的上皮的房间线 A549.Methods A.fumigatus 为 A.fumigatus blastospores 的粘附和 endocytosis 决定 E-cadherin 的角色的坚持的 neutropenia.This ， blastospores 与 A549 的全部的蛋白质被孵化调查 E-cadherin 和 blastospor 的绑定

英文摘要：

Background Aspergillus fumigatus （A.fumigatus） is a ubiquitous saprophytic fungus responsible for the majority of invasive mold infections in patients undergoing chemotherapy,organ transplantation or with persistent neutropenia.This study aimed to determine the role of E-cadherin for adhesion and endocytosis of A.fumigatus blastospores in the human epithelial cell line A549.Methods A.fumigatus blastospores were incubated with the total protein of A549 to investigate the binding of E-cadherin and blastospores followed by an affinity purification procedure.After establishing the adhesion model,the adhesion and endocytosis of A.fumigatus blastospores by A549 cells were evaluated by down-regulating E-cadherin of A549 cells using blocking antibody or small interfering RNA （siRNA）.Results E-cadherin was adhered to the surface of A.fumigatus blastospore.Adhesion and endocytosis of the blastospores were reduced by blocking or down-regulating E-cadherin in A549 cells.Conclusions E-cadherin is a receptor for adhesion and endocytosis of A.fumigatus blastospores in epithelial cells.This may open a new approach to treat this fungal infection.