中文摘要：

目的 探讨血小板相关参数与单采血小板输注疗效之间的相关性,为临床诊断提供指导意义。方法 通过回顾性的分析本院2014-2016年输注单采血小板的患者50例,根据首次输注1个治疗量血小板后d 5复查血常规结果,血小板计数升至正常范围为增长组（27人）,血小板计数未达正常范围为降低组（23人）。分别比较分析2组输注前和输注后24 h内血小板相关系数包括血小板计数（Plt）,血小板分布宽度（PDW）,平均血小板体积（MPV）,大血小板比率（P-LCR）的改变,同时计算24 h血小板纠正计数指数（CCI）。结果 24 h CCI〉4.5增长组有21例占77.78%,降低组有11例占47.83%;输注前血小板相关参数两组间比较没有显著差异（P〉0.05）,输注后,增长组Plt,PDW,MPV和P-LCR明显高于降低组（P〈0.01）;其中输血前后数据相比较增长组MPV,P-LCR全部增高,降低组MPV,P-LCR则全部降低。结论 血小板参数检测特别是MPV和P-LCR的改变趋势对于血小板输注的疗效观察与预后判断具有重要的临床意义。

英文摘要：

Objective To evaluate the clinical significance of detecting platelet parameters in platelet transfusion patients by Investigating the relationship between platelet parameters and efficacy of platelet transfusion and prognosis. Methods A total of 50 patients who underwent platelet transfusion in our hospital in 2014 to 2016 were reviewed. Patients divided into two groups （with normal platelet counts group or subnormal platelet counts group） according to outcomes of blood biochemistry and routine after five days of platelets transfusion. Platelet parameters （ platelet count, platelet distribution width, mean platelet volume, large platelet ratio） and CCI were evaluated by statistical analysis. Results The numbers of patients with CCI〉4. 5 in normal platelet counts group is 21（77.78% ）, that in subnormal platelet counts group is 11 （47.83%）. Platelet parameters before transfusion showed no significant difference between two groups （P〉0.05）. After transfusion, in normal platelet counts group Pit, PDW, MPV and P-LCR were significantly higher than another group （P〈0. 01）. MPV and P-LCR were increased in normal platelet counts group, and decreased in normal platelet counts group after transfusion. Conclusion Detection of platelet parameters, especially MPV and P-LCR, is important for evaluating the efficacy and prognosis of platelet transfusion.