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中文摘要：
采用热聚合方法，以D-萘普生（D—Npx）为模板分子，N-异丙基丙烯酰胺（NIPAAm）为功能单体，N，N’-亚甲基双丙烯酰胺（MBAA）和二甲基丙烯酸乙二醇酯（EGDMA）分别为交联剂，制备了一种温敏D-INpx分子印迹凝胶（MIH），研究了凝胶的温敏性以及交联剂的种类和浓度对凝胶结构和分离性能等的影响。研究结果表明，随着MBAA含量的增加，MIH的平衡溶胀率降低，且MIH对D—Npx的吸附和脱附量先增加后逐渐减少；随EGDMA含量的增加，MIH对D—Npx的吸附和脱附量逐渐增大。MIH具有明显的温敏性，MBAA含量对凝胶的最低临界溶解温度（LCST）几乎没有影响，凝胶表现出较好的溶胀-退胀性，脱附率可达90％以上。
英文摘要：
A novel thermo sensitive D naproxen （D-Npx） molecularly imprinted hydrogels （MIH was prepared by thermal polymerization with D-Npx as the template molecule, N-isopropylacrylamide as functional monomer, N, N＇- methylene bis-acrylamide and ethylene glycol dimethacrylate as cross linking agent, respectively. The thermo-sensitivity and the influences of the cross-linking agent on structure and separation performance of the hydrogels were investigated. The results showed that the equilibrium swelling ratio of MIH decreased with the increase of the concentration of MBAA, and adsorption and desorption amount of D-Npx increased firstly and then decreased. The adsorption and desorption amount of D-Npx increased continually with the increase of the concentration of EGDMA. MIHs exhibit obvious thermo-sensitivity. The concentration of MBAA had little effect on the lower critical solution temperature （LCST） of the hydrogels, and MIHs exhibited excellent reverse swelling-deswelling property, the maximum of desorption amount of D-Npx could reach up to 90%.
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