中文摘要：

rapamycin 的哺乳动物的目标， mTOR，形成各种各样的蛋白质蛋白质建筑群响应营养素和房间的精力地位调整房间生长。最近，大热重复蛋白质 mTOR 的第一水晶结构表明胖领域通过静电的效果和恐水病的相互作用与 kinase 领域交往。基于结构，胖领域怎么调整 mTOR 活动的以前的研究被考察。DEPTOR 当前作为一个内长的 mTOR 禁止者被知道，它可以与 mTOR 脂肪领域交往在 vivo 压制 mTOR 活动。有 mTOR 脂肪领域的 DEPTOR 的可能的相互作用也被分析。另外， DEPTOR 的抑制机制可能类似于包含热的 RanGTP 复杂家庭的成员，提供进 mTOR kinase 规定的新机械学的卓见。

英文摘要：

The mammalian target of rapamycin, mTOR, forms various protein-protein complexes to regulate cell growth in response to the nutrient and energy status of the cell. Recently, the first crystal structure of large HEAT repeat protein mTOR revealed that the FAT domain interacts with the kinase domain through electrostatic effects and hydrophobic interactions. Based on the structure, the previous researches on how FAT domain regulates mTOR activity are reviewed. DEPTOR is currently known as an endogenous mTOR inhibitor, which may interact with roTOR FAT domain to suppress mTOR activity in vivo. The possible interactions of DEPTOR with the mTOR FAT domain are analyzed, too. In addition, the inhibition mechanism of DEPTOR may be similar to members of HEAT-involved RanGTP complex family, providing new mechanistic insights into mTOR kinase regulation.