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中文摘要：
肿瘤病毒病因的研究已经历了一个世纪,近半个世纪以来确立了7种人类肿瘤病毒,初步阐明了人类肿瘤病毒致病机制的复杂性及其特殊规律.人类基因组测序结果表明约8％的基因由人类内源性反转录病毒（HERV）组成,成年人T细胞白血病病毒（HTLV）与成年人T细胞白血病、动物的外源性和内源性反转录病毒与肿瘤及恶性疾病关系的证实,引发了对HERV与人类肿瘤发生、发展关系的关注和研究.文章介绍了白血病和实体瘤中HERV的表达及其与病情的关系.HERV与肿瘤的关系可能是肿瘤病毒学的一个重要方面,不仅有重要的理论意义,还有潜在的应用前景.
英文摘要：
Viral etiology of tumor has been studied for a century.Seven human tumor viruses were identified over the past half century.The complexity and regularity of the pathogenic mechanisms of human tumor viruses have been elucidated preliminarily.Human genome sequencing indicated that 8 % of human genes were composed of human endogenous retroviruses （HERVs）.Owing to the findings that adult T-cell leukemia virus （HTLV） can cause human adult T-cell leukemia and animal exogenous and HERVs can induce tumors and malignant diseases,the relationship between HERVs and human tumors has attracted much attention receutly.Here this article discusses the association of the expression of HERVs with leukemia and solid tumors progression,which may be an important aspect of tumor virology.
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