中文摘要：

随着对皮肤生物学功能认识的深入,人们发现皮肤是一个内分泌器官和激素、神经递质敏感性器官。皮肤的神经-内分泌系统包括局部产生神经-内分泌介导子（neuro-endocrine mediators）,与相应的特异性受体通过旁分泌和自分泌产生作用,在组

英文摘要：

Accumulating evidence has indicated that the skin can serve as a peripheral neuroendocrine organ,and is also a target organ of hormones and neurotransmitters.The cutaneous neuroendocrine system plays a critical role in tissue repair and regeneration through their special receptors in the paracrine or autocrine manner.Renin-angiotensin system（RAS）is one of the several important hormonal systems,which regulates global and local homeostasis.During the last decade,completely new aspects have emerged in the field of RAS research.It is clear that angiotensin Ⅱ（Ang Ⅱ）,a key peptide of RAS,plays a role not only in regulation of blood pressure and body fluids but also in cell proliferation and differentiation.Ang Ⅱ has been showed to be involved in cutaneous self-turnover,embryonic development as well as repair and remodeling.This review mainly presents the evidence that skin is a source and target organ of RAS,and RAS plays roles in cutaneous wound repair and regeneration.