中文摘要：

Z-藁本内酯是中药川芎中主要的苯酞类化合物，具有神经保护、抗炎、抗增值及扩张血管等多种药理作用。但Z-藁本内酯在自然条件不稳定且易于降解，限制其研究和应用。本文采用HPLC-uv、UPLC-QTOF-MS和NMR对Z．藁本内酯室温自然光照下的降解行为及降解产物进行考察和鉴定，Z-藁本内酯完全降解后生成5个降解产物，2个降解产物通过与对照品对比确定为洋川芎内酯I和洋川芎内酯H，2个降解产物采用半制备HPLC分离后进行1H和13C NMR解析，确定其结构为（E）-6，7-反式．双羟基藁本内酯和（Z）-6，7-环氧藁本内酯。最后推测了Z-藁本内酯的降解途径，氧化、水解和异构化是主要的降解反应。

英文摘要：

Z-Ligustilide, a major phthalide isolated from a widely used traditional Chinese medicine Ligusticum chuanxiong, possesses various pharmacological activities including neuroprotective, anti-inflammatory, anti- proliferative and vasorelaxing effects. However, it is unstable and inclined to degrade in natural conditions, which limits its study and application greatly. In this study, degradation behavior of Z-ligustilide and its degradation products stored at room temperature under direct sunlight were investigated and structure elucidated by HPLC-UV, UPLC-QTOF-MS and NMR. Z-ligustilide degradation and total five degradation products were generated and detected. Two degradation products were unequivocally identified as senkyunolide I and senkyunolide H by comparison with reference compounds. Another two degradation products were further isolated by semi-preparative HPLC and structure elucidated as （E）-6, 7-trans-dihydroxyligustilide and （Z）-6, 7- epoxyligustilide by IH and 13C NMR, respectively. The degradation pathways of Z-ligustilide were finally proposed. Oxidation, hydrolysis and isomerization are the major degradation reactions.