中文摘要：

目的 探讨广西巴马长寿老人TH01等15个STR多态位点与长寿的关系.方法 调查巴马长寿区长寿老人167例（长寿组）,非长寿区的长寿老人22例（对照1组）,非长寿区无长寿家族史的健康对照者134例（对照2组）.采用多色荧光标记的聚合酶链反应-短串联重复序列（PCR-STR）技术及自动测序法,检测各组人群TH01等15个STR位点等位基因分型.比较长寿组和各对照组等位基因及基因型频率的差异.结果 长寿组分别与各对照组相比频率有差异（P〈0.05）的等位基因或基因型如下： TH01-A10、CSF1PO-A9、TH01A9-10频率低于对照1组;D19S433-A17、D7S820-A10、D7S820-A11频率高于对照2组, D7S820-A12/A13/A14三个等位基因、vWA-A17、D8S1179-A15、D5S818 A10-12低于对照2组.结论 巴马长寿群体有着自己特有的、异于其他地区长寿群体的STR等位基因分布.在巴马长寿人群中发现了TH01、CSF1PO、vWA、D19S433、D7S820、D5S818、D8S1179等位点等位基因的置换或突变可能与长寿或衰老的进程相关.

英文摘要：

Objective To explore the correlation of 15 short tandem repeats （STR） loci containing TH01 and natural longevity in Bamaa county. Methods 167 longevous individuals from longevity region in Bama were recruited as the longevity group. In Bama non-longevity region, 22 longevous individuals were selected as control group 1 and control group 2 was composed of 134 residents without longevity family history. Muhiplex PCR amplification and genetic analyzer were applied to detect and analyze the genetic polymorphisms of 15 STR loci. Chi square test was performed to analyze the differences of frequencies of alleles and genotypes between longevity group and each control group. Results There were statistically significant changes of some frequencies of alleles and genotypes between longevity group and each control group （P 〈0. 05）. Decreased frequencies of TH01-A10, CSF1PO-A9, TH01 A9-10 were observed in longevity group, when compared with that in control group 1. In the longevity group, the frequencies of D19S433-A17, D7S820-A10, D7S820-A1 1 were higher and fre- quencies of D7S820-A12/A13/A14, vWA-A17, D8S1179-A15, D5S818 A10-12 were lower than those in control group 2. Conclusions The unique STR allele distributions in Bama longevous population differ from that of longevous population in other geographic areas. The replacement or mutation of TH01, CSF1PO, vWA, D19S433, DTS820, D5S818, D8S1179 loci may be related to longevity and aging-related processes.