中文摘要：

在急性感染和传统感染模式中，宿主利用固有免疫机制应对一系列病原体的入侵。然而，一些病原菌可以成功逃避、抑制或颠覆免疫检测、信号转导或有效杀伤。该文就病原菌如何操纵宿主细胞的防御功能，调节胞内杀伤、信号转导，破坏固有免疫系统受体间分子信号的交联作用，并最终使微生物在宿主体内适应性生长、持续感染等方面作一综述。

英文摘要：

The innate immune mechanisms are utilized by host to prevent a range of bacteria in acute and conserved infectious pattern. However, successful intracellular pathogens can evade, inhibit or subvert immune detection, signalling transduction or effective damages. In this review, we focus on how bacterial pathogens manipulate host-cell defence system and regulate intracellular killing or signaling, and how to disrupt the molecular signal- ing crosstalk between receptors of the innate immune system, eventually contibuting to bacterial adaptive fitness and persistent infections in the host.