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A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population

分类：Q782[生物学—分子生物学] S511[农业科学—作物学]
作者机构：[1]Department of Epidemiology and Biostatisties, MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China, [2]Medieal Laboratory, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu 225001, China, [3]Department of Gastroenterology, Yangzhou First People's Hospital, Yangzhou, Jiangsu 225009, China, [4]Seetion of Clinical Epidemiology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu 210029, China
相关基金：supported by grants from National Natural Science Foundation of China（No.81001276 and No.81072380）; a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions

作者： Yao Liu[1], Qin Zhang[1], Chuanli Ren[2], Yanbing Drag[3], Guangfu Jin[1,4], Zhibin Hu[1,4], Yaochu Xu[1], Hongbing Shena[1,2]

关键词： MET, 变异体, 易感性, 胃癌, 中国人口, Logistic回归分析, 种系, 肝细胞生长因子, MET, germline variation, gastric cancer, susceptibility

中文摘要：

遇见的酷氨酸 kinase 和它的 ligand， hepatocyte 生长因素(HGF ) ，在肿瘤细胞的 activties 起一个枢轴的作用。在 exon 的 germline 错误感觉变体 2 遇见的基因， N375S (rs33917957 A > G ) ，可以改变有约束力的亲密关系为 HGF 并且这样相遇了修改 tumorigenesis 的风险。在这研究，我们执行了盒子控制研究在 1,681 个胃的癌症盒子和 1,858 没有癌症的控制中估计在 N375S 和胃的癌症风险之间的协会。逻辑回归分析被使用为在遗传型和胃的癌症风险之间的协会估计粗略、调整的机会比率(ORs ) 和 95% 信心间隔(CI ) 。我们发现遇见的 N375S 变体遗传型(NS/SS ) 与胃的癌症的显著地减少的风险被联系(或 = 0.78， 95% CI = 0.63-0.96， P = 0.021 ) 与 wildtype 同质接合体(NN ) 相比。发现显示那这 germline 变体在相遇可以减少用汉汉语的胃的癌症危险性。

英文摘要：

MET tyrosine kinase and its ligand,hepatocyte growth factor（HGF）,play a pivotal role in the activties of tumor cells.A germline missense variant in exon 2 of the MET gene,N375S（rs33917957 A〉G）,may alter the binding affinity of MET for HGF and thus modify the risk of tumorigenesis.In this study,we performed a case-control study to assess the association between N375S and gastric cancer risk in 1,681 gastric cancer cases and 1,858 cancer-free controls.Logistic regression analysis was applied to estimate crude and adjusted odds ratios（ORs） and 95% confidence intervals（CIs） for the associations between genotypes and gastric cancer risk.We found that MET N375S variant genotypes（NS/SS） were associated with a significantly decreased risk of gastric cancer（OR = 0.78,95% CI = 0.63-0.96,P = 0.021） compared with the wildtype homozygote（NN）.The finding indicates that this germline variant in MET may decrease gastric cancer susceptibility in Han Chinese.

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