中文摘要：

目的比较细菌性肝脓肿在2型糖尿病患者与非2型糖尿病患者中的临床特点与转归，以期指导临床诊断与治疗。方法回顾性分析安徽医科大学第一附属医院110例细菌性肝脓肿患者的临床资料，其中合并2型糖尿病者（糖尿病组）和非2型糖尿病者分别为45例和65例。比较两组患者的临床症状及体征，实验室检查结果，病原学检查结果，影像学表现，治疗方法及预后等。正态分布的计量资料两组之间的比较采用独立样本t检验，计数资料两两比较采用卡方检验或Fisher确切概率法。多因素Logistic回归分析影响两组预后的危险因素。结果糖尿病组和非糖尿病组首发症状为发热者分别有37例和40例，右上腹痛分别为7例和22例，两组比较差异均有统计学意义（χ2值分别为5.417、4.582，均P〈0.05）。中性粒细胞计数分别为（12.87±8.83）×109/L和（10.24±4.86）×109/L，中性粒细胞比例分别为0.841±0.077和0.799±0.103，白蛋白分别为（28.36±4.65） g/L和（30.67±6.16） g/L，差异均有统计学意义（t值分别为2.010、2.317、－2.265，均P〈0.05）。尿素氮升高者分别为13例和8例，肌酐升高者分别为9例和4例，差异均有统计学意义（χ2值分别为4.733、4.892，均P〈0.05）。非糖尿病组脓液培养阳性9例（9/13），血培养阳性6例（6/25，24.0%）；糖尿病组脓液培养阳性13例（13/19），血培养阳性7例（7/21，33.3%）。两组肺炎克雷伯菌培养阳性率分别为37.5%（15/40）和15.8%（6/38），差异有统计学意义（χ2＝4.669，P＝0.031）。糖尿病组积极控制血糖后两组病例有效率分别为84.4%（38/45）和84.6%（55/65），病死率分别为2.2%（1/45）和1.5%（1/65）。多因素Logistic回归分析显示，多发脓肿（OR＝34.61，95%CI：1.601～748.457，P＝0.024）为糖尿病组预后的危险因素，及时行侵入性治疗（OR＝0.028，95%CI：0.001～0.984，P＝0.049）?

英文摘要：

ObjectiveTo compare the clinical characteristics and prognosis of bacterial liver abscess in patients with or without type 2 diabetes mellitus, in order to guide clinical diagnosis and treatment.MethodsThe clinical data of 110 patients with bacterial liver abscess at the First Affiliated Hospital of Anhui Medical University were retrospectively analyzed. Among them, 45 cases with type 2 diabetes mellitus and 65 cases without type 2 diabetes mellitus were included in the study. The demographic data, clinical signs and symptoms, laboratory findings, pathogenic results, imaging findings, treatment and prognosis were compared between the two groups. Differences among the quantitative data with normal distribution were compared using t test, while count data were compared with χ2 test or Fisher exact test. Multivariate Logistic regression was used to determine the prognostic risk factors of two groups.ResultsFever as initial symptom in diabetic group and non-diabetic group were 37 cases and 40 cases, respectively, while abdominal pain presented in 7 cases and 22 cases of the two groups, respectively, both with statistically significant difference （χ2=5.417 and 4.582, respectively, both P〈0.05）. As for laboratory examination, neutrophil counts in the two groups were （12.87±8.83）×109/L and （10.24±4.86）×109/L, respectively, the percentages of neutrophils were 0.841±0.077 and 0.799±0.103, respectively, albumin levels were （28.36±4.65） g/L and （30.67±6.16） g/L, respectively, with statistically significant difference （t=2.010, 2.317 and -2.265, respectively, all P〈0.05）. Patients with elevated blood urea nitrogen in the two groups were 13 cases and 8 cases, respectively, patients with elevated creatinine were 9 cases and 4 cases, respectively, with statistically significant difference （χ2=4.733 and 4.892, respectively, both P〈0.05）. In diabetic group, pus culture was positive in 13 out of 19 cases, and blood culture was positive in 7 out of 21 cases. In non-diabetic group, pus cu