医用钛植入体材料的细菌感染问题是影响植入手术失败的重要原因之一,为获得具有良好抗细菌感染能力,在乙酸锌的溶液中利用水热反应将阳极氧化TiO2纳米管阵列转化为ZnTiO3/TiO2复合纳米管阵列结构(NT-Zn),利用扫描电子显微镜(SEM),X射线衍射仪(XRD),X射线光电子能谱(XPS)分析了样品的形貌、结构和成分。体外抗菌和细胞黏附与增殖实验表明,NT-Zn涂层具有良好的抗细菌感染能力,同时具有良好的细胞活性,无细胞毒性。
Development of simple and stable implants having both enhanced biological activity and antibacterial property is of scientific and clinical significance.In this study,titania nanotubes(NTs) incorporated with zinc(NT-Zn) were produced on Ti implants by anodization and hydrothermal treatment in Zn containing solutions.The suitable NT-Zn coatings with good intrinsic antibacterial properties can prevent post-operation infection.No obvious cytotoxicity is observed from NT-Zn samples compared to the Ti control.The NT-Zn structure which is simple,stable,and easy to produce and scale up has immense potential in implant applications.