目的正交设计优选黄芩栀子合煎工艺。方法采用正交试验法,考察加水量、煎煮时间、煎煮次数对黄芩、栀子合煎液中栀子苷含量、黄芩苷含量及干膏得率的影响。结果优选出的最佳提取工艺为:加8倍量水,提取3次,每次0.5h。结论所优选的工艺稳定、合理、可行,可为合理开发含有黄芩、栀子药对的复方制剂提供理论依据。
Objective To optimize the mixed decoction technology for Scutellaria baicalensis and Gardenia jasminoides by orthogonal design.Methods An orthogonal test was performed to investigate the influences of the amount of water,decocting time,and times of decoction on the content of geniposide and baicalin and the yield of dry extract from the mixed decoction solution of Scutellaria baicalensis and Gardenia jasminoides.Results The optimized extraction process was as follows:adding water(8times),and extracting 3times(0.5heach time).Conclusion The optimized process is stable,reasonable,and feasible.This study can provide a theoretical basis for the development of compound preparation of Scutellaria baicalensis and Gardenia jasminoides.