中文摘要：

Mesoporous 硅石 nanoparticles (MSN ) 广泛地作为众多的生物医学的应用的有希望的候选人被学习了并且求婚。在这研究，我们报导设计，准备，描述和肽 dendron functionalized mesoporous 硅石 nanohybrid 的 biosafety 评估。这 nanohybrid 被 MSN 的表面修正与 alkynyl 肽 dendrons 经由 azido-MSNs 的按反应准备，并且由 TEM 描绘了， SEM， TGA，散布的动态光(DLS ) 。在 vitro， nanohybrid 的 cytotoxicity 被 CCK-8 试金与不同房间线作比较。在里面 vivo 毒性评估被身体重量移动，血例程测试和组织学的分析测量，建议肽 functionalized nanohybrid 由于非观察的重要副作用拥有了好 biocompatibility 到健康鼠标的正常机关。总的来说，就我们的结果而言，我们相信肽 dendron functionalized mesoporous 硅石 nanohybrid 在进一步生物医学的应用是很有希望的。

英文摘要：

Mesoporous silica nanoparticles (MSNs) have been extensively studied and proposed as promising candidates for numerous biomedical applications.In this study,we report the design,preparation,characterization and biosafety evaluation of peptide dendron functionalized mesoporous silica nanohybrid.This nanohybrid was prepared by surface modification of MSNs via click reaction of azido-MSNs with alkynyl peptide dendrons,and characterized by TEM,SEM,TGA,dynamic light scattering (DLS).In vitro cytotoxicity of the nanohybrid was evaluated against different cell lines by CCK-8 assay.The in vivo toxicity evaluation was measured by body weight shift,blood routine test and histological analysis,suggesting that the peptide functionalized nanohybrid possessed good biocompatibility due to the non-observed significant side effects to normal organs of healthy mice.Overall,considering our results we believe that the peptide dendron functionalized mesoporous silica nanohybrid is very promising in further biomedical applications.