中文摘要：

从异乙酰香草酮出发，经过烷基化、Wittig—Homer、溴代、酞酰亚胺化、不对称还原和脱保护-环化反应6步合成了（R）-咯利普兰，总收率达到了34％。目标产物的结构经过核磁和质谱的确证。

英文摘要：

The synthetic method on （R） -rolipram was described in detail. Using isoacetovanitlone as materials, （R） - rolipram was synthesized by six steps of alkylation, Wittig - Homer, bromo reaction, phthalimide, enantioselective conjugate reduction and deprotection followed by cyclization reaction. The product yield was 34%. The structure of the product was determined by ^1H NMR and MS.