中文摘要：

目的：研究扇贝裙边糖胺聚糖（SS—GAG）抗动脉粥样硬化作用机制。方法：将培养的U937细胞分为正常组、模型组和SS～GAG不同浓度组，除正常组外，其余组加入氧化低密度脂蛋白造模后给予相应浓度药物进行处理，分别采用不同方法测定各组细胞超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH—Px）活性和一氧化氮（NO）含量及Ca^2＋水平。结果：各组中SOD含量无显著性差别；SS—GAG组中GSH—Px活性和NO含量与模型组比较明显升高，而细胞内Ca^2＋水平则明显降低。结论：SS—GAG可能通过增强GSH-Px活性和NO释放，同时降低细胞内Ca^2＋水平而发挥抗动脉粥样硬化作用。

英文摘要：

OBJECTIVE： To study the mechanism of anti - atherosclerosis action of glycosaminoglyean from scallop skirt （SS-GAG） . METHODS： The incubated U937 cells were divided into normal group, model group and SS GAG groups （at different concentrations）. All groups except the normal group were treated with drugs （at a corresponding concentration） after modeling with oxidized low density lipoprotein （LDL） . The SOD level, GSH-Px activity and NO concentration and the intracellular Ca^2 ＋ in each group were measured respectively by different methods. RESULTS： No significant differences were noted among groups in SOD level. However, as compared with model group, GSH- Px activity and NO concentrations in SS- GAG groups were significantly increased, but the intraeellular Ca^2＋ level was significantly decreased. CONCLUSION： The mechanism of the anti - atherosclerosis action of SS- GAG may be attributed to its ability to increase GSH - Px activity and the releasing of NO meanwhile decreasing the intracellular Ca^2 ＋ level in foam cells.