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中文摘要：
目的研究液体目标治疗后应用山莨菪碱对脓毒症休克患者乳酸清除率的影响。方法选2010年10月至2012年10月收住ICU的18岁以上脓毒症休克患者，随机分配为液体目标治疗＋山莨菪碱组（治疗组）和对照组，观察两组患者动脉血乳酸（LAC）及乳酸清除率的变化。结果液体目标治疗＋山莨菪碱组LAC明显低于对照组同期，差异具有统计学意义（P〈0．05），同时，液体目标治疗＋山莨菪碱治疗组入选后24h乳酸清除率均明显高于对照组同期，差异具有统计学意义（P〈0．01）。结论液体目标治疗后，应用山莨菪碱，可以明显提高脓毒症休克患者的乳酸清除率。
英文摘要：
Objective To study the lactate clearance effect of high-dose anisodamine after liquid target treatment in patients with septic shock. Methods Patients with septic shock above 18 years old at the ICU from October 2010 to October 2012 were randomly divided into the anisodamine group （received anisodamine treatment after liquid target treatment） and the control group. LAC and lactate clearance were recorded. Results Compared with the control group, the LAC in anisodamine group was significantly lower （P 〈0.05）. Meanwhile, lactate clearance rate of the anisodamine group was statistically higher than that in the control group after 24 h （P 〈0.01）. Conclusions Application of anisodamine after liquid target treatment can significantly improved lactate clearance rate of patients with septic shock.
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