中文摘要：

目的探讨幽门螺杆菌感染与非甾体抗炎药致消化性溃疡并出血的相关性，为临床防治提供参考依据。方法对医院2010年1月-2011年12月120例消化性溃疡患者的临床资料进行回顾性分析，将其按照是否出血分为出血组50例和非出血组70例；采用SPSS19．0统计软件进行数据处理，计量资料采用t检验，计数资料采取x^2检验，应用非条件logistic回归分析进行多因素分析。结果两组患者的单因素分析显示，年龄≥60岁、伴有既往消化道出血史、心脑血管病史和使用非甾体抗炎药物4项因素组间比较差异有统计学意义（P＜0．05）；多因素logistic分析显示，年龄≥60岁、消化性溃疡病史、消化道出血病史、幽门螺杆菌感染和使用非甾体抗炎药物均是影响消化性溃疡并出血的危险因素（P＜0．05）。结论临床中单纯的幽门螺杆菌感染并不会增加消化性溃疡并出血的危险，年龄≥60岁、消化性溃疡病史、心脑血管病史、消化道出血病史、幽门螺杆菌感染和使用非甾体抗炎药物等因素同时出现可增加消化性溃疡并出血的危险性，临床中应引起足够重视。

英文摘要：

OBJECTIVE To explore the correlation between the Helicobacter pylori infection and peptic ulcer bleeding induced by non-steroidal anti-inflammatory drug so as to provide guidance for clinical prevention and treatment. METHODS The clinical data of 120 patients with peptic ulcer who were treated in the hospital from Jan 2010 to Dec 2011 were retrospectively analyzed, then the subjects were divided into the bleeding group with 50 cases and the non-bleeding group with 70 cases according to the status of bleeding; the statistical analysis was performed with the use of SPSS19.0 software, the measurement data were analyzed by using the t-test, the count data were analyzed by means of the chi-square test, and the non-conditional multivariate logistic regression analysis was performed. RESULTS The univariate analysis indicated that the difference in the no less than 60 years of age, history of gastrointestinal bleeding, history of cardiovascular disease, or use of non-steroidal anti-inflammatory drug between the two groups was significant （P〈0.05）. The multivariate logistic analysis showed that the no less than 60 years of age, history of peptic ulcer, history of gastrointestinal bleeding, H. pylorl infection, and use of non-steroidal anti-inflammatory drug were the risk factors for peptic ulcer bleeding （P〈0.05）. CONCLUSION The H. pylori infection may not increase the risk of peptic ulcer bleeding;the no less than 60 years of age, history of peptic ulcer, history of cardiovascular disease, history of gastrointestinal bleeding, H. pylori infection, and use of nonsteroidal anti-inflammatory drug can increase the risk of peptic ulcer bleeding, which should be paid high attention to.