中文摘要：

离子型γ-氨基丁酸（GABA）受体主要介导神经和肌肉细胞中快速的抑制性突触传递。昆虫离子型GABA受体的RDL亚基是环戊二烯类和苯基吡唑类杀虫剂的分子靶标,但目前至少有19种昆虫已报道产生了抗性突变;同时还发现昆虫编码RDL亚基的基因可通过可变剪切和RNA编辑等方式形成多种亚型,从而导致受体功能的多样性,这也为开发新型杀虫剂提供了条件。主要对该杀虫剂靶标的分子生物学、生理功能以及药理学等方面的最新研究成果进行综述。

英文摘要：

The ionotropic GABA receptor mediates the fast synaptic inhibition in the nerve and muscle cells. Insect ionotropic GABA receptor（RDL subunit） is an important molecular target of the cyclodiene and phenylpyrazole insecticides, however, it has been reported that there are at least 19 species of insects that have the mutations to these pesticides, and revealed a diversity of subunit isoforms arising from the alternative splicing and RNA editing of GABA receptor genes in various insect species, which may lead to functional diversity of GABA receptors and develop new specific insecticides for pest management. In this review, we summarized the current knowledge on the molecular biology, physiological function and pharmacology of ionotropic GABA receptors.