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人体测量学指标与多重代谢异常的非线性典型相关分析
  • ISSN号:1000-8020
  • 期刊名称:卫生研究
  • 时间:2013.9.9
  • 页码:730-735
  • 分类:R181.2[医药卫生—流行病学;医药卫生—公共卫生与预防医学] R589[医药卫生—内分泌;医药卫生—临床医学;医药卫生—内科学]
  • 作者机构:[1]郑州大学公共卫生学院,郑州450001, [2]郑州大学基础医学院
  • 相关基金:教育部高等学校博士学科点专项科研基金(No.20094101120011);国家自然科学基金(No.81001280,81202277);河南省科技攻关项目(No.112102310198)
  • 相关项目:棕色脂肪细胞分化、凋亡、产热相关基因的基因-基因、基因-环境交互作用致肥胖研究
中文摘要:

目的明确人体测量学指标整体与多重代谢异常症状整体的关系,以期对代谢综合征(metabolic syndrome,MS)的预防提出针对性的建议。方法采用随机整群抽样的方法,以河南省某县为研究现场对常住成年居民进行问卷调查、体格检查和血生化指标检测。采用SPSS13.0的OVERALS过程进行非线性典型相关分析,并计算典型相关系数、多元相关系数,并绘制各指标关联强度的重心图。结果共获得调查对象2914人,其中男性1134人(38.9%)、女性1780人(61.1%),平均年龄(50.58±13.70)岁。非线性典型相关的拟合结果为:损失量为0.577,占总变异的28.8%,相对较小,说明两组变量,即生化指标总胆固醇、总甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和空腹血糖与性别、年龄、体质指数及腰围之间的相关程度较大,常有同步变化趋势;多元相关系数显示各生化检测指标之间和性别、年龄及人体测量学指标之间均存在较强的内部相关,即常出现整体异常现象。各指标关联强度的重心图表明随着年龄增长代谢异常症状增多;女性代谢异常症状较多;超重及肥胖人群伴有多代谢异常;腰围与代谢畀常呈正相关。结论(1)生化指标、人体测量学指标组合变化的几率高;(2)年龄较大人群,特别是中老年男性及老年女性是一级预防的重点人群;(3)超重和腹型肥胖可作为预测多代谢异常的敏感指标;(4)非线性典型相关和重心图在分析多组变量时具有优势。

英文摘要:

Objective To define the general correlation between anthropometric indicators and multiple metabolic abnormalities, and to put forward some particular suggestions for the prevention of multiple metabolic abnormalities. Methods A random cluster sampling was carried out in one county of Henan Province. Questionnaire, physical examination and biochemical tests were admitted to the adult inhabitants. Non-linear canonical correlation analysis (NLCCA) was applied with OVERALS of SPSS 13.0. The coefficients of canonical correlation and multiple correlation were calculated. The plot of centroids labeled by variables showed the correlation among various indicators. Results In total, 2 914 objects were investigated. It included 1 134 (38.9%) males and 1 780 (61.1%) females (60. 0% ). The average age was(50. 58 ± 13.70)years old. The fitting result of NLCCA were as follows: the loss of 0. 577 accounting for 28.8% of the total variation was relatively small, and indicated that the two sets of variables of this study, namely sets of biochemical indicators (including serum total cholesterol, total triglyceride, high-density lipoprotein cholesterol, low density lipoprotein cholesterol and fasting plasma glucose) and sets of others (including gender, BMI and waist circumference ) were closely related and often changed synchronously. Multivariate correlation coefficient showed that internal indicators of the above two sets were closely related respectively and often showed the multiple anomalies of the same set. The diagram of the center of gravity of the association of various indicators showed that the symptoms of metabolic abnormalities increased with age. Women were more liable to have metabolic abnormalities. Overweight and obese people often suffer multiple metabolic disorders. Waist circumference was positively correlated with metabolic abnormalities. Conclusion ( 1 ) Biochemical indicators and anthropometric often change in combination. (2)Much attention should be paid to older peopl

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期刊信息
  • 《卫生研究》
  • 北大核心期刊(2011版)
  • 主管单位:国家卫生和计划生育委员会
  • 主办单位:中国疾病预防控制中心
  • 主编:段国兴
  • 地址:北京市西城区南纬路29号
  • 邮编:100050
  • 邮箱:wsyj2012@126.com
  • 电话:010-83132376 83132329
  • 国际标准刊号:ISSN:1000-8020
  • 国内统一刊号:ISSN:11-2158/R
  • 邮发代号:82-720
  • 获奖情况:
  • 国家双百期刊,第二届国家期刊奖百种重点期刊,1997年《卫生研究》荣获第二届全国优秀期刊二等奖
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘(网络版),荷兰文摘与引文数据库,美国生物医学检索系统,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版),英国英国皇家化学学会文摘,中国北大核心期刊(2000版)
  • 被引量:22260