中文摘要：

目的：比较PVB与PF方案对局部晚期宫颈癌患者PTEN、VEGF和CD105表达的影响。方法：选取我院妇科收治的局部晚期宫颈癌患者150例,随机分为两组,其中PVB组75例予顺铂、长春新碱、博来霉素化疗;PF组75例予博来霉素、顺铂配合5-氟尿嘧啶治疗。观察并对比治疗前后患者临床疗效及患者癌组织PTEN、VEGF表达阳性率、CD105抗体标记的肿瘤MVD值等指标。结果：1治疗后两组PTEN、VEGF表达阳性率均有所改善,与PVB组（76.3%）比较,PF组PTEN表达阳性率（88.3%）明显升高,差异有统计学意义（P〈0.05）;与PVB组（15.3%）比较,PF组VEGF表达阳性率（6.7%）明显降低,差异有统计学意义（P〈0.05）;2治疗后两组MVD值均有所改善,与PVB组（38.93±9.89）比较,PF组MVD值（35.61±10.33）明显降低,差异有统计学意义（P〈0.05）;3治疗后,与PVB组（76.67%）比较,PF组的有效率（86.67%）明显较高,差异有统计学意义（P〈0.05）。结论：与PVB方案相比,PF方案能够使局部晚期宫颈癌患者PTEN表达水平升高,降低VEGF和CD105表达水平,临床疗效更确切。

英文摘要：

Objective： To compare the effect of PVB and PF regimens on the expression of PTEN, VEGF and CD105 in locally advanced cervical cancer patients. Methods： 150 patients with locally advanced cervical cancer in our hospital were selected for gynecological patients, then they were randomly divided into two groups; 75 cases in group PVB, treated with cisplatin, vincristine,bleomycin chemotherapy; 75 cases in group PF, treated with bleomycin, cisplatin combined with 5- fluorouracil treatment. The curative effects and the positive expression rate of PTEN, VEGF and CD105 antibody labeled tumor MVD value index were compared before and after treatment between the two groups. Results： 1After treatment, the positive expression rate of PTEN and VEGF were improved in the two groups, and for the PF group, PTEN expression was obviously increased and VEGF expression was significantly decreased with statistical significance compared with that in the PVB group（P〈0.05）; 2 after the treatment, the value of MVD of both groups was improved, and MVD was decreased more significantly in the PF group than in the PVB group（P〈0.05）; 3 in comparison of efficiency rate, it was significantly higher in the PF group than in the PVB group, and the difference was statistically significant（P〈0.05）.Conclusions： Compared with PVB scheme, PF scheme can increase PTEN expression level of the patients with locally advanced cervical cancer, as well as decrease VEGF and CD105 expression level, therefore, PF scheme has a more exact clinical curative effect.