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中文摘要：
目的探讨雌激素对阿尔茨海默病（AD）大鼠模型的学习记忆能力及N-甲基-D天冬氨酸受体-1（NMDAR1）表达的影响。方法大鼠卵巢切除术（OVX）后给予雌激素替代治疗（ERT）,然后采用Aβ1～40,1μl（10μg/μl）立体定位单侧海马内注射建立AD动物模型,通过水迷宫实验检测动物模型的学习、记忆能力;免疫组化检测NMDAR1的蛋白表达情况。结果 ERT组AD动物模型的水迷宫逃避潜伏期较OVX组明显缩短（P〈0.05）;同时ERT组AD动物模型的海马CA1、CA3区的NMDAR1的蛋白表达上调（P〈0.05）。结论雌激素可以改善AD动物模型的认知功能;其神经保护作用可能与上调NMDAR1的蛋白表达有关。
英文摘要：
Objective To investigate the influence of estrogen on learning and memory and the expression of N-methyl-D-aspartate receptor-1 （NMDAR1） in rats′ model of Alzheimer′s disease （AD）.Methods Rats were given ovariectomy （OVX）,and estrogen replacement therapy （ERT）.AD rat model was established by injection of amyloid-beta peptide （Aβ）_1～40 1 μl （10 μg/μl） into the hippocampus.Learning and memory ability was determined by Morris water maze.The expression of NMDAR1 was assessed by immunohistochemistry method.Results The escape latency of Morris water maze was decreased in ERT group compared with the OVX group （P〈0.05）.At the same time the expression of NMDAR1 was higher in CA1,CA3 area and frontal lobe cortex in ERT group than those of OVX group （P〈0.05）.Conclusions ERT can improve cognitive deficits in AD rats′ model,which may be related to increasing the expression of NMDAR1 in hippocampus.
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