中文摘要：

探讨脑内深部髓质静脉（deepmedullaryveins，DMVs）特征表现和颈内静脉（internaljugulrveins，IJVs）改变与多发性硬化（multiplesclerosis，MS）的关系。方法对30例复发缓解型MS患者和30例年龄、性别匹配的非MS对照组行常规磁共振成像（magneticresonanceimaging，MRI）、三维增强E加权血管成像（3-dimensionalenhancedE-weightedangiography，3-DESWAN）和3-D时间分辨率对比剂动力成像（time-resolvedimagingofcontrastkinetics，TRICKs）扫描。观察患者和对照组侧脑室体旁DMVs在3-DESWAN改变并评分；比较患者与对照组DMVs评分和UVs狭窄发生率的差异，并评价DMVs和UVs改变分别与EDSS评分和病程的相关性。结果①MS患者DMVs评分（1．67±0．25）较对照组（3．00±0．00）显著降低（P〈0．01）；16例病程〉2．0年者为1分，8例病程0．5—2．0年者为2分，二者与对照组比较差异均有统计学意义（P〈0．01），6例病程〈0．5年者与对照组比较差异无显著性（P〉0．05）。9个慢性病灶“穿通静脉”扩张和延长。②5例（16．7％）MS患者和2例（6．7％）对照组患者IJVs狭窄，2组UVs狭窄发生率差异无统计学意义（P〉0．05）。③IJVs狭窄与DMVs减少无显著相关性（P〉0．05）。④DMVs减少、变短与患者病程呈显著负相关（r=0．89，P〈0．01），与EDSS评分无显著相关性（r=0．05，P〉0．05）；IJVs狭窄与EDSS评分和病程均无显著相关性（Z=0．20，P〉0．05；Z=3．46，P〈0．05）。结论MS患者DMVs改变与IJVs狭窄无显著相关性。

英文摘要：

study the correlation of cerebral deep medullary vein （DMV） characteristics and changes in internal jugular vein （IJV） with multiple sclerosis （MS）. Methods Thirty recurrent remittent MS patients （MS group ） and 30 age- and sex-matched controls （control group ） underwent conventional magnetic resonance imaging （MRI）, 3-dimensional （3-D） enhanced T2 -weighted angiography （ ESWAN ）, and 3-D time-resolved imaging of contrast kinetics （TRICK）. Changes in periventricular DMV of MS group and control group were observed on 3-D ESWAN and scored. Results The periventricular DMV score was signifi- cantly lower in MS group than in control group （ 1.67±0.25 vs 3. O0±0.00, P 〈0.01 ）. The course of MS was 〉2.0 years in 16 patients with 1 score and 0.5±2.0 years in 8 patients with 2 scores （P〈0.01）, and 〈0.5 year in 6 patients （ P 〉 0.05 ）. Dilated and prolonged penetrating veins were found in 9 chronic MS lesions. IJV stenosis was observed in 5 （16.7%） MS patients and 2 （6.7%） controls, respectively （P 〉0. 05）. The IJV stenosis was not significantly correlated with the reduced DMV （P 〉 0.05 ）. The reduced and shortened DMV were positively correlated with the course of MS （ r = - 0.89, P 〈 0.01 ） but negatively correlated with the expanded disability status scale （EDSS） score （r = 0.05, P 〉 0.05 ）. The IJV stenosis was not significantly correlated with the EDSS score and the course of MS （Z = 0.20, P 〉 0.05 ; Z = 3.46, P 〈 0.05）. Conclusion Changes of periventrieular DMV are not significantly correlated with HV stenosis in MS natients.