Immunization with HBsAg-Fc fusion protein induces a predominant production of Thl cytokines and reduces HBsAg level in transgenic mice
- ISSN号：0366-6999
- 期刊名称：《中华医学杂志：英文版》
- 时间：0
- 分类：Q78[生物学—分子生物学] S942.5[农业科学—水产养殖;农业科学—水产科学]
- 作者机构：[1]Shanghai Public Hlealth Clinical Center, Key Lab of MedicalMolecular Virology, Shanghai Medical College, Institutes ofBiomedical Sciences, Fudan University, China Shanghai 200433, [2]Intern-ational Joint Cancer Institute & Chinese People's LiberationArmy General Hospital Cancer Center, Second Military MedicalUniversity, China Shanghai 200433
- 相关基金：This study was supported by the grants from the ＂973＂ Project （No. 2005CB522902）, the National Science and Technology Key Project on Infectious Diseases （No. 2008ZX10002-010, 015）, the National Science and Technology Key Project on Novel Drugs （No. 2009ZX09303-006）, and the Shanghai Municipal Government （No. 07DJ14006, No. 8410706800, and No. 10ZR1402300）.
关键词：
细胞免疫应答, HBSAG, 转基因小鼠, 融合蛋白, 细胞因子, 诱导, 丙氨酸氨基转移酶, 乙肝表面抗原, Fc receptor, hepatitis B surface antigen transgenic mice, hepatitis B virus, therapeutic vaccine
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