中文摘要：

目的 探讨Ezrin蛋白及磷酸化Ezrin （phos-Ezrin）在皮肤鳞癌中的表达及临床意义.方法 采用免疫组化法检测20例皮肤正常组织（NS）、31例脂溢性角化组织（SK）、36例基底细胞癌组织（BCC）、37例皮肤鳞癌（SCC）中Ezrin、phosEzrin蛋白的表达,分析Ezrin、phos-Ezrin表达与皮肤癌病理组织类型、临床分期和肿瘤转移的相关性.结果 （1）Ezrin蛋白在NS、SK、BCC、SCC中的阳性表达率分别为20.0％、25.8％、66.7％和89.2％,phos-Ezrin蛋白阳性率分别为10.0％、22.6％、77.8％、94.6％,癌组织中的Ezrin和phos-Ezrin表达显著高于非癌组织（P＜0.01）.（2）Ezrin,phos-Ezrin蛋白的表达与皮肤肿瘤组织类型（R1 =0.87,0.89）、SCC病理分级（R2 =0.80,0.86）及淋巴转移（R3 =0.89,0.91）密切相关（P＜0.01）.结论 Ezrin,phos-Ezrin表达与皮肤肿瘤的类型、恶性程度（病理分级）和淋巴结转移有关.Ezrin,phos-Ezrin联合检测可为预测皮肤恶性肿瘤转移及预后提供参考.

英文摘要：

Objective To investigate the expressions of Ezrin and phos-ezrin in squamous cell carcinomas （SCC）,and to an alyze their clinic significance.Methods Immunohistochemistry was used to detect the expressions of Ezrin and phos-Ezrin in 20 cases of normal skin,31 cases of seborrheic Keratosis （SK）,36 cases of basal cell carcinoma （BCC）,and 37 cases of SCC.Results （1） The positive rates of Ezrin in normal skin （NS）,SK,BCC,and SCC were 20.0%,25.8%,66.7%,and 89.2%,respectively.The positive reates of phos-Ezrin in NS,SK,BCC,and SCC were 10.0 %,22.6%,77.8%,and 94.6%,respectively.Ezrin and phos ezrin in cancers were higher than that in noncancer tissues （P 〈 0.01）.（2） The expressions of Ezrin,and phos-Ezrin were closely correlated with the cutaneous tumor＆#39;s type（R1 =0.87,r1 =0.89,P 〈 0.01）,malignant degree （patho-grading of SCC） （R2 =0.80,r2=0.86,P 〈 0.01）,metastasis via lymph node （R3 =0.89,r3 =0.91,P 〈 0.01）.Conclusions Ezrin and phos-Ezrin expressions were closely related to the types of tumor,malignant degrees,and metastasis.The combined-detection of Ezrin and phos-ezrin would provide a novel clue to predicting metastasis and prognosis of cutaneous tumor.