中文摘要：

目的探讨补肾柔肝法治疗卵巢早衰的临床疗效。方法将130例卵巢早衰患者随机分为3组，治疗组50例口服补肾柔肝中药颗粒，草药组50例口服补肾柔肝中药水煎剂，对照组30例口服倍美力加用安宫黄体酮，6个月为1个疗程。于给药前后分别测定血清雌二醇（E2）、促卵泡激素（FSH）的水平及外周血T淋巴细胞亚群CD4＋、CD8＋，同时观察烘热汗出、阴道干涩、腰膝酸痛、烦躁抑郁等更年期症状的改善情况。结果补肾柔肝中药给药后E2水平均显著升高（P均〈0．05），FSH水平均显著降低（P均〈0．05），CD4＋细胞增加，CD8＋细胞减少，CD4＋／CD8＋比值提高（P均〈0．05），临床症状明显改善。且中药颗粒剂与中药煎剂临床疗效等同。结论补肾柔肝中药能极大地改善卵巢早衰患者的生活质量，恢复和改善卵巢功能，同时提高机体免疫能力，安全而有效。

英文摘要：

Objective It is to explore the clinical curative effect of Bushenrougan therapy in treating premature ovarian failure. Methods 130 cases with premature ovarian failure were randomly divided into three groups. The patients in control group（30 cases） were treated with premarin and medroxyprogesterone while the patients in treatment group（50 cases） were treated with Bushenrougan granule, the patients in traditional Chinese herb group（50 cases） were treated with Bushenrougan decoction. Six months was one treatment course. The level of serum estradiol （ E2 ） , follicle-stimulating hormone （FSH） and T lymphocyte subsets CD4 ＋ , CD8＋ in peripheral blood were determined before and after treatment, and the improvements of the menopausal symptoms as aching pain of waist and knees, manic-depressive, vaginal dryness, heated sweating and so on were observed at the same time. Results The level of serum E2 , CD4 ＋ cells,and the ratio of CD4＋/CD8＋ was significantly in- creased（ P 〈 0.05 ） , the level of serum FSH and CD8＋ cells was decreased （P 〈0. 05 ） , and the clinical symptoms were im- proved obviously after administration with traditional Chinese medicine for Bushenrougan. There was no significant difference in the clinical curative effect between granule and decoction. Conclusion TCM for Bushenrougan, safe and effective, could greatly improve the quality of life in patients with premature ovarian failure, restore and improve ovarian function, at the same time it could improve the immunity of the organism.