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中文摘要：
目的：为研究B淋巴细胞刺激因子（BLyS）参与类风湿性关节炎（RA）的发病机制及其靶向治疗药物提供文献支持。方法：综述了BLyS的生物学特性、参与RA的发病机制以及靶向于BLyS治疗RA的新药研究等方面的内容。结果：BLys是一种Ⅱ型跨膜蛋白，由285个氨基酸纽成，其作为胂瘤坏死因子家族的新成员，对B淋巴细胞的增殖活化起重要调节作用；BLyS的过表达与RA等自身免疫病的发病机制和疾病进程关系密切；以BLys为靶点的治疗RA的药物（Belimumab、BR3-Fc、TACI-Ig）经临床试验证实取得了良好的治疗效果。结论：BLyS参与了RA等自身免疫病的发病机制，是具有高度特异性的新靶点，故研制BLyS拮抗药将成为RA等自身免疫病高效且安全的免疫治疗方法。
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