中文摘要：

建立了以非手性离子液体1-正丁基-3-甲基咪唑氯（[BMIM]Cl）为手性分离的添加剂、β-环糊精作为手性选择剂的毛细管区带电泳（CZE）分离扑尔敏、氯霉素前体和氧氟沙星3种对映体的方法,并与未添加[BMIM]Cl的CZE分离情况进行了对比研究。发现[BMIM]Cl对手性药物的拆分有协同作用,不仅能够增加对映体的分离度,还能有效地抑制毛细管内壁对样品分子的吸附作用,改善峰形。采用离子液体辅助手性选择剂（尤其是环糊精）的CZE改进方法,为其他毛细管电泳难以分离的手性药物的分离分析提供了新的方法。

英文摘要：

Using an achiral ionic liquid,1-butyl-3-methylimidazolium chlorine（[BMIM]Cl）,as an additive and beta-cyclodextrin（β-CD）as a chiral selector,the enantiomers of chlorpheniramine,the precursor of chloramphenicol and ofloxacin were separated by capillary zone electrophoresis.This work was directed to the study of the association of [BMIM]Cl to the chiral selector β-CD and the possible effects of [BMIM]Cl on chiral separation.Simultaneously,the separation performances were studied when only containing β-CD in the buffer.The results showed that there are synergistic effects of [BMIM]Cl as an additive for the enantiomeric separations.[BMIM]Cl can not only remarkably increase the separation selectivity and resolution of the enantiomers,but also effectively restrain the adsorption of the sample molecules and improve the peak shape.[BMIM]Cl as an additive of chiral separation can provide a new method for the separation of chiral drugs which are hard separable under common electrophoresis conditions.