中文摘要：

肿瘤的发生与肿瘤细胞所处的内外环境有着密切关系,肿瘤微环境中存在着一群具有免疫抑制作用的髓源性天然免疫细胞,即髓系来源的抑制性细胞（MDSCs）。近年来,多项研究指出MDSCs在肿瘤微环境中通过分泌多种具有抑制T淋巴细胞免疫作用的物质,借助多种分子通道,使肿瘤组织得以逃脱机体免疫监视,直接或间接地促进肿瘤的生长、侵袭和转移。通过抑制MDSCs的生成、活化、效应途径从而阻断其免疫抑制作用已逐渐成为肿瘤治疗的新领域。

英文摘要：

There is a close relationship between the tumorigenesis and tumor microenvironment. There exists a subpopulation of immunosuppressive innate immune cells derived from bone marrow, which are myeloid-derived suppressor cells（MDSCs）. In recent years, many studies have pointed that MDSCs prevents tumors from the immunosurveillance of body and promotes the development, invasion and metastasis of tumor via a variety of molecular pathways and secretion of components which have a kind of ability of inhibiting T-cells. The inhibition on generation, activation and function of MDSCs has gradually become a new field of tumor therapy.