Huperzine A,从繁体中文植物提取的活跃石松子碱,是一个有势力,选择、可逆的 acetylcholinesterase (疼痛) 禁止者并且广泛地为 Alzheimer 的疾病(广告) 的治疗在中国被使用了。因此,为 huperzine A 的行动的一些新机制在过去的十年被发现了。除了它的疼痛禁止的效果,通过激活胆碱能的系统并且直接对线粒体起作用的有势力 multifaceted neuroprotective 效果被探索了。而且,以便最大化 huperzine 的功效和安全治疗,大努力被作了优化药交货系统。在现在的文章,被尝试为 huperzine 讨论当前的进步和未来观点在广告的治疗。
Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (ACHE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). Accordingly, some new mechanisms of action for huperzine A have been discovered over the past decades. In addition to its AChE inhibitory effect, potent multifaceted neuroprotective effect through activating cholinergic system and directly acting on mitochondria have been explored. Moreover, in order to maximize the efficacy and safety of huperzine A therapy, great efforts have been made to optimize drug delivery system. In the present article, an attempt is made to discuss the current progress and future perspective for huperzine A therapy in AD.