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Investigation of Myocardial Stunning after Cardiopulmonary Resuscitation in Pigs
  • ISSN号:0895-3988
  • 期刊名称:Biomedical and Environmental Sciences
  • 时间:0
  • 页码:155-162
  • 分类:Q510.3[生物学—生物化学] TM92[电气工程—电力电子与电力传动]
  • 作者机构:[1]Hyperbaric Oxygen Department, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China, [2]Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
  • 相关基金:supported by the National Natural Science Foundation of China (No. 30972863)
  • 相关项目:传统心肺复苏与单纯持续心外按压对肺通气/血流比值、氧代谢和自主循环建立的影响
中文摘要:

在心肺的复活(CPR ) 以后在 48 h 期间调查心脏的功能和心肌的灌注的目的,对测试进一步心肌叹为观止并且在 CPR 以后为长期的幸存寻求指示物。在未经治疗的室的纤维性颤动的 4 min 以后的方法,十五头 anesthetized 猪在基线和 2 h 被学习,在自发的循环(ROSC ) 的恢复以后的 4 h, 24 h,和 48 h。血液动力学的数据, echocardiography 和门单人赛光子排放计算了断层摄影术心肌的灌注图象被执行。结果平均数动脉的压力(地图) ,冠的灌注压力(CPP ) 和心脏的 troponin (CTNI ) 我在 ROSC 以后在 4 h 显示出最终的幸存动物和非幸存动物之间的重要差别(109.2

英文摘要:

Objective To investigate cardiac function and myocardial perfusion during 48 h after cardiopulmonary resuscitation (CPR), further to test myocardial stunning and seek indicators for long‐term survival after CPR. Methods After 4 min of untreated ventricular fibrillation, fifteen anesthetized pigs were studied at baseline and 2 h, 4 h, 24 h, and 48 h after restoration of spontaneous circulation (ROSC). Hemodynamic data, echocardiography and gated‐single photon emission computed tomography myocardial perfusion images were carried out. Results Mean arterial pressure (MAP), coronary perfusion pressure (CPP) and cardiac troponin I (CTNI) showed significant differences between eventual survival animals and non‐survival animals at 4 h after ROSC (109.2±10.7 mmHg vs. 94.8±12.3 mmHg, P=0.048; 100.8±6.9 mmHg vs. 84.4±12.6 mmHg, P=0.011; 1.60±0.13 ug/L vs. 1.75±0.10 ug/L, P=0.046). Mitral valve early‐to‐late diastolic peak velocity ratio, mitral valve deceleration time recovered 24 h; ejection faction and the summed rest score recovered 48 h after ROSC. Conclusion Cardiac systolic and early active relaxation dysfunctions were reversible within survival animals; cardiac stunning might be potentially adaptive and protective after CPR. The recovery of MAP, CPP, and CTNI could be the indicators for long‐term survival after CPR.

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期刊信息
  • 《生物医学与环境科学:英文版》
  • 主管单位:卫生部
  • 主办单位:中国疾病预防控制中心
  • 主编:陈春明
  • 地址:北京昌平区昌百路155号中国CDC
  • 邮编:102206
  • 邮箱:bes@chinacdc.cn
  • 电话:010-58900401 58900445传
  • 国际标准刊号:ISSN:0895-3988
  • 国内统一刊号:ISSN:11-2816/Q
  • 邮发代号:
  • 获奖情况:
  • 首届国家优秀期刊三等奖,第三届中国出版政府奖提名奖
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,荷兰文摘与引文数据库,美国生物医学检索系统,美国科学引文索引(扩展库),美国生物科学数据库,日本日本科学技术振兴机构数据库
  • 被引量:330