中文摘要：

目的：分析侵蚀性葡萄胎的各种化疗方案及其不良反应。方法：对2006～2011年收治的侵蚀性葡萄胎患者74例进行回顾性分析。结果：患者解剖学分期：Ⅰ期25例,Ⅱ期2例,Ⅲ期47例。根据预后评分分组：低危组（≤6分）67例,高危组（≥7分）7例。MTX单药化疗25例,VMP方案化疗30例,FAVE方案化疗5例,VFA方案化疗2例,化疗过程中出现耐药而更换治疗方案者12例。行全子宫切除术6例。随访时间7～75个月,失访3例,其余随访HCG均在正常范围内。结论：侵蚀性葡萄胎患者以肺转移多见,治疗上以MTX单药、VMP化疗方案为主,耐药者可选择VMP、EMA-CO、FAEV或TP方案,HCG降至正常时无生育要求者及时切除子宫。

英文摘要：

Objective：To analyze the chemotherapy and its side effects of the invasive mole.Methods：Clinical data of 74 patients with invasive mole from January 2006 to December 2011 were collected and analyzed retrospectively.Results：According to the anatomic stages,25 patients were at stage Ⅰ,2 patients were at stage Ⅱ,47 patients were at stage Ⅲ.Based on the prognostic score grouping,67 patients were in low-risk group（≤6 score）;while 7 patients were in high-risk group（＆gt;7 score）.25 patients were treated with MTX,30 patients were treated with VMP,5 patients were treated with FAVE,2 patients were treated with VFA,12 patients with drug-resistant were replaced with other therapy regimen.6 patients were applied with hysterectomy during the chemotherapy.The follow-up time was from 7 to 75 months,besides 3 patients were not connected,serum HCG value of the rest patients were within the normal range.Conclusion：Lung metastasis is common in patients with invasive mole.MTX and VMP chemotherapy are the main regimen for the treatment of the invasive mole.As for the patients with drug-resistant,VMP,EMA-CO,FAVE,or TP can be chosen for the latter therapy,and the hysterectomy is recommended for the patients without the need of pregnancy after the value of HCG is dropped to normal.