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Epigenetic regulation of adipocyte differentiation and adipogenesis
  • 时间:0
  • 分类:Q343[生物学—遗传学]
  • 作者机构:[1]Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beo'ing Normal University, Beijing 100875, China, [2]Reproductive Medicine Research Center, the First Hospital of Lanzhou University, Lanzhou 730000, China, [3]Beijing Key Laboratory of Engineered Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing 100875, China, [4]Biomedicine Research Institute, College of Life Sciences, Beijing Normal University, Beijing 100875, China, [5]Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China
  • 相关基金:Project supported by the National Natural Science Foundation of China (Nos. 31071027 and 30870926), the National Key Technology R&D Program of China (No. 2008BAC39B05), and the Fund from Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education and Beijing Key Laboratory of Engineered Drug and Biotechnology, Beijing Normal University, China
  • 相关项目:孕烷X受体(PXR)调控肝脏脂质代谢的分子机制
中文摘要:

adipocytes 从在能被划分成二个过程的间充质的干细胞发源,这通常被同意:决心和区别。在过去的十年,与 epigenetic 信号联系的许多因素被证明了为 adipogenesis 前进的适当预定枢轴。在批评基因倡导者的很多 coregulators 建立了 DNA 的特定的模式 methylation, histone acetylation 和 methylation,和 nucleosome 重新整理,充当 epigenetic 代码在 adipogenesis 期间调制 adipocyte 区别和 adipogenesis 的正确进步。在这评论,我们在 preadipocyte 区别和 adipogenesis 集中于 epigenetic 过程的功能和角色。

英文摘要:

It is generally agreed that adipocytes originate from mesenchymal stem cells in what can be divided into two processes: determination and differentiation. In the past decade, many factors associated with epigenetic signals have been proved to be pivotal for the appropriate timing of adipogenesis progression. A large number of coregulators at critical gene promoters set up specific patterns of DNA methylation, histone acetylation and methylation, and nucleosome rearrangement, that act as an epigenetic code to modulate the correct progress of adipocyte differentiation and adipogenesis during adipogenesis. In this review, we focus on the functions and roles of epigenetic processes in preadipocyte differentiation and adipogenesis.

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