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寻常痤疮中医证素与性激素关系的研究

ISSN号：1673-1727
期刊名称：《中华中医药杂志》
时间：0
分类：R587.1[医药卫生—内分泌;医药卫生—临床医学;医药卫生—内科学] R758.733[医药卫生—皮肤病学与性病学;医药卫生—临床医学]
作者机构：[1]福建中医学院中医系,福州350108, [2]福建省石狮市医院皮肤科,石狮361000, [3]台湾中国医药大学中药研究所,台中
相关基金：福建省科技三项经费资助项目（No,20031010）

作者：李灿东[1], 蔡东华[2], 闵莉[1], 高碧珍[1], 张永動[3]

关键词：痤疮, 证, 性激素, 证素, 临床研究, Acne vulgaris, Syndrome, Sexual hormone, Syndrome element, Clinical research

中文摘要：

目的：探讨寻常痤疮证素（证的要素）规律及其内分泌机制。方法：采用流行病学方法调查青年学生1484人;选择70例痤疮患者为对象,15名健康人为对照,以证素辨证和性激素为指标。结果：痤疮患病率66.9%;病位证素属肝比例最大,肾次之;病性证素中属热者比例最大,阴虚次之（P﹤0.01）。男性患者肝郁化火和肺经风热组睾酮（T）非常显著高于对照组（P﹤0.01）;肝郁化火组T非常显著高于湿热蕴脾组（P﹤0.01）;肝郁化火组的黄体生成激素/卵泡刺激素（LH/FSH）显著高于心火旺盛型、肺经风热、肾虚火旺组（P﹤0.05或P﹤0.01）;湿热蕴脾组的LH/FSH显著高于心火旺盛和肺经风热组（P﹤0.05）。女性患者性激素组间差异不显著（P〉0.05）。结论：痤疮病位以肝、肾为主,病性以热证多见,证候形成与性激素变化有关。

英文摘要：

Objective： To study the rule of TCM syndrome elements and the endocrine mechanism in acne vulgaris. Methods： 1484 adolescent students were investigated with the method of epidemiologic survey. Meanwhile, the indexes of sexual hormones and TCM syndrome elements differentiation were used in 70 patients with acne vulgaris, and 15 healthy persons as control. Results： 1.The attack rate was 66.9%. The rate of syndrome element of the disease location, liver was the highest and kidney was the second（P〈0.01）. The rate of syndrome element of the disease nature, heat was the highest and yin deficiency was the second（P〈0.01）. 2. In male patients, the testosterone （T） in the group of fire due to liver depression and in the group of windheat of lung was higher than that in control group（P〈0.01）. The LH/FSH in the group of fire due to liver depression was highest and that in the group of spleen damp-heat was the second （P〈0.01, P〉0.05）. In female patients, the sexual hormones between different syndrome group showed no difference （P〉0.05）. Conclusion： The location of acne is liver and kidney which manly manifested as the heat syndrome. The syndrome is co-related to the changes of sexual hormones.

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