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中文摘要：
目的研究急性心肌梗死患者的肿瘤坏死因子-α（TNF-α）水平与心肌梗死后室性心律失常发生之间的关系。方法确诊急性心肌梗死患者65例，在不同时间点检测其心肌酶谱（cTnI、CK、CK—MB、AST、LDH）及TNF-α表达水平，并监测其心律失常情况，进行相关性分析。结果血浆TNF-α水平与心肌酶谱表达呈正相关（P〈0．05），TNF-α表达与心肌梗死后室性期前收缩Lown分级呈正相关（P〈0．05），急性前壁心肌梗死患者TNF-α水平较其他部位梗死患者高（均P〈0．05）。结论急性心肌梗死后TNF-α表达水平与室性心律失常存在一定关系，心肌梗死后室性心律失常发生多的患者其TNF-α表达水平高。
英文摘要：
Objective To investigate the relationship between tumor necrosis factor-α（TNF-α） levels in acute myocardial infarction （AMI） patients and post-AMI ventricular arrhythmias. Methods Sixty-five AMI patients were confirmed. The plasma levels of myocardial enzyme （TnI 、CK、CK-MB、GOT、LDH）and TNF-α were observed at different times after AMI. Arrhythmias were monitored too. The relationships between them were analyzed. Results The plasma levels of TNF-α were positively correlated with myocardial enzyme （ P 〈 0.05 ）. The plasma levels of TNF-α werc positively correlated with the Lown classification of premature ventricular contraction （ PVC ） after AMI （ P 〈 0.05 ）. The plasma levels of TNF-α were higher in AMI of anterior wall than other positions （ P 〈 0.05 ）. Conclusion There is a relationship between TNF-α level after AMI and ventricular arrhythmias. The plasma levels of TNF-α are higher when the rate of ventricular arrhythmias is higher.
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