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Sperm Mitochondria in Reproduction： Good or Bad and Where Do They Go？
  • ISSN号：1673-8527
  • 期刊名称：《遗传学报：英文版》
  • 时间：0
  • 分类：Q959.468[生物学—动物学] Q954.434[生物学—动物学]
  • 作者机构：[1]Key Ixlboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingtkto 266109. China, [2]Department of Veterinary Pathobiology, University Missouri, Columbia, MO 65211, USA 'State Key Ltlboratory of Reproductive Biology, Institute of Zoolog., [3]Chinese Academy of Sciences Beijing 100101, China
  • 相关基金：supported by the Major Basic Research Program(Nos.2012CB944404 and 2011CB944501);the National Natural Science Foundation of China(No.30930065)to Q.Y.S
作者： Shi-Ming Luo[1], Heide Schatten[2], Qing-Yuan Sun[1,3]
关键词： 线粒体DNA, 精子, 繁殖, 哺乳动物, 受精能力, 早期胚胎发育, 氧化磷酸化, mtDNA, Mitochondrial DNA, Maternal inheritance, Paternal inheritance, Autophagy, Oxidative phosphorylation, Ubiquitination
中文摘要：

The mitochondrion is the major energy provider to power sperm motility.In mammals,aside from the nuclear genome,mitochondrial DNA(mtDNA) also contributes to oxidative phosphorylation to impact production of ATP by coding 13 polypeptides.However,the role of sperm mitochondria in fertilization and its final fate after fertilization are still controversial.The viewpoints that sperm bearing more mtDNA will have a better fertilizing capability and that sperm mtDNA is actively eliminated during early embryogenesis are widely accepted.However,this may be not true for several mammalian species,including mice and humans.Here,we review the sperm mitochondria and their mtDNA in sperm functions,and the mechanisms of maternal mitochondrial inheritance in mammals.

英文摘要：

The mitochondrion is the major energy provider to power sperm motility. In mammals, aside from the nuclear genome, mitochondrial DNA （mtDNA） also contributes to oxidative phosphorylation to impact production of ATP by coding 13 polypeptides. However, the role of sperm mitochondria in fertilization and its final fate after fertilization are still controversial. The viewpoints that sperm bearing more mtDNA will have a better fertilizing capability and that sperm mtDNA is actively eliminated during early embryogenesis are widely accepted. However, this may be not true for several mammalian species, including mice and humans. Here, we review the sperm mitochondria and their mtDNA in sperm functions, and the mechanisms of maternal mitochondrial inheritance in mammals.

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哺乳动物卵子减数分裂纺锤体检验点和染色体分离机制研究
期刊论文 77
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期刊信息
  • 《遗传学报：英文版》
  • 北大核心期刊（2004版）
  • 主管单位:中国科学院
  • 主办单位:中国科学院遗传与发育生物学研究所 中国遗传学会
  • 主编：薛勇彪
  • 地址：北京市安定门外大屯路中科院遗传发育所
  • 邮编：100101
  • 邮箱：ycxb@genetics.ac.cn
  • 电话：010-64807669
  • 国际标准刊号：ISSN：1673-8527
  • 国内统一刊号：ISSN：11-5450/R
  • 邮发代号:2-819
  • 获奖情况:
  • 1996年获中科院优秀期刊二等奖,1997年获全国优秀期刊三等奖,200年获中科院优秀期刊二等奖
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,英国农业与生物科学研究中心文摘,波兰哥白尼索引,荷兰文摘与引文数据库,荷兰医学文摘,美国生物医学检索系统,美国科学引文索引（扩展库）,美国生物科学数据库,英国动物学记录,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2000版）
  • 被引量:17519