中文摘要：

采用电喷雾质谱和圆二色谱研究了溶液pH和阳离子对人类端粒G-四链体DNA的影响.ESI-MS和CD谱图表明,pH可以引起G-四链体DNA的构象转变和离解,而K^＋,NH4^＋阳离子对G-四链体DNA的形成有着重要的促进作用.

英文摘要：

　Electrospray ionization mass spectrometry and circular dichroism were used to investigate the factors which affect the motif of the human telomeric quadruplex,such as pH and cations.ESI-MS and CD spectra indicated that pH could induce both the conformational transition and the dissociation of the quadruplex.Moreover,K^＋ and NH4^＋ cations play an important role in the formation of the quadruplex.