中文摘要：

胰腺癌的发生发展与许多信号通路如：Hedgehog（Hh）、Wnt/Notch、K-ras、TGF-β等途径都有关系,Hh信号通路是其核心之一,主要由配体蛋白（Hh蛋白）、膜受体（Ptch和Smo）、核转录因子Gli蛋白家族、HSC（Hh信号复合体）和调节因子等组成,在胰腺癌中Hh信号通路100%的相关分子存在基因突变。该文主要从Hedgehog信号通路的组成、关键位点、调节作用以及与胰腺癌的关系进行总结,为寻求中医药防治恶性肿瘤的新途径和作用靶点提供实验理论依据。

英文摘要：

The development and progression of pancreatic cancer related many signaling pathway such as ： Hedgehog （ Hh ）, Wnt/Notch, K-ras, a TGF- beta pathway, Hh signaling pathway is one of the core, mainly by the ligand protein （ Hh protein ）, membrane receptors （ Ptch and Smo ）, a nuclear transcription factor Gli protein family, HSC （ Hh signaling complex ） and adjustment factor components, Hh signaling pathway related molecules exist in 100% of the gene mutation in pancreatic cancer. Mainly s the composition, key sites and relationship with pancreatic cancer of Hedgehog signaling pathway provide the experimental basis for the new way for Chinese traditional medicine for the treatment of malignant tumor and target.