中文摘要：

NY-ESO-1抗原是肿瘤-睾丸抗原家族中的重要成员,在多种类型的肿瘤中广泛表达,并且是迄今发现的最具免疫原性的肿瘤抗原,可以在NY-ESO-1表达阳性的肿瘤患者体内引起自发性体液免疫反应和特异性T细胞免疫反应。因此,NY-ESO-1被认为是最好的肿瘤候选疫苗,在肿瘤免疫治疗中最具发展潜力。本文主要介绍了近年来有关NY-ESO-1抗原以及相关疫苗的研究进展。

英文摘要：

NY-ESO-1 is an important member of cancer-testis antigen family and is widely distributed among many cancer types.As a tumor-specific antigen with the strongest immunogenicity so far identified,it can induce spontaneous antibody and T-cell responses in patients with NY-ESO-1-positive tumors.Therefore,it has been a good vaccine candidate in the immunotherapy against many malignancies.This article reviews the recent research advances in NY-ESO-1 and its relevant vaccines.